Abnormal cortical activity in patients with temporomandibular disorder evoked by cognitive and emotional tasks

I. Weissman-Fogel, M. Moayedi, H. C. Tenenbaum, M. B. Goldberg, B. V. Freeman, K. D. Davis

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with temporomandibular disorder (TMD) perform poorly in neuropsychological tests of cognitive function. These deficits might be related to dysfunction in brain networks that support pain and cognition, due to the impact of chronic pain and its related emotional processes on cognitive ability. We therefore tested whether patients with TMD perform poorly in cognitive and emotion tasks and whether they had abnormal task-evoked brain activity. Seventeen female subjects with nontraumatic TMD and 17 age-matched healthy female subjects underwent functional magnetic resonance imaging while performing counting Stroop tasks comprising neutral words, incongruent numbers, or emotional words, including TMD-specific words. Group differences in task-related brain responses were assessed. Connectivity between 2 pairs of coupled brain regions during the cognitive and emotional tasks (prefrontal-cingulate and amygdala-cingulate) was also examined. The patients had sluggish Stroop reaction times for all Stroop tasks. Furthermore, compared to controls, patients showed increased task-evoked responses in brain areas implicated in attention (eg, lateral prefrontal, inferior parietal), emotional processes (eg, amygdala, pregenual anterior cingulate), motor planning and performance (eg, supplementary and primary motor areas), and activation of the default-mode network (medial prefrontal and posterior cingulate). The patients also exhibited decoupling of the normally correlated activity between the prefrontal and cingulate cortices and between the amygdala and cingulate cortex. These findings suggest that the slow behavioral responses in idiopathic TMD may be due to attenuated, slower, and/or unsynchronized recruitment of attention/cognition processing areas. These abnormalities may be due to the salience of chronic pain, which inherently requires attention. Sluggish performance in cognitive and emotional interference tasks in patients with nontraumatic temporomandibular disorder is associated with pronounced and unsynchronized task-evoked fMRI brain responses.

Original languageEnglish
Pages (from-to)384-396
Number of pages13
JournalPain
Volume152
Issue number2
DOIs
StatePublished - Feb 2011
Externally publishedYes

Bibliographical note

Funding Information:
This study was funded by a Canadian Institute of Health Research (CIHR) grant. Dr. Weissman-Fogel was funded by a CIHR Strategic Training Program (Pain: Molecules to Community) and a clinician-scientist fellowship from the University of Toronto Centre for the Study of Pain. Mr. Moayedi is funded by a CIHR studentship, an Ontario Graduate Scholarship, and the CIHR Pain: M2C and Cell Signals Strategic Training in Health Research grants. Dr. Davis is a Canada Research Chair in Brain and Behaviour. We thank Mr. Geoff Pope, Dr. Adrian Crawley, Mr. Eugene Hlasny and Mr. Keith Ta for expert technical assistance. The authors would like to thank Dr. Yair Lenga for patient screening.

Keywords

  • Chronic pain
  • Cognition
  • Cortex
  • Emotion
  • Stroop
  • TMD
  • fMRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Anesthesiology and Pain Medicine

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