A two-state electronic antigen and an antibody selected to discriminate between these states

Arbel Artzy-Schnirman; Elad Brod; Malki Epel; Monica Dines; Tal Hammer; Itai Benhar; Yoram Reiter; Uri Sivan

doi:10.1021/nl8020895

A two-state electronic antigen and an antibody selected to discriminate between these states

Arbel Artzy-Schnirman, Elad Brod, Malki Epel, Monica Dines, Tal Hammer, Itai Benhar, Yoram Reiter, Uri Sivan

Research output: Contribution to journal › Article › peer-review

Abstract

Inspired by biology where pathways are triggered and suppressed by specific binding of two molecules, we realize a functional interface between electronics and biology by replacing one of the pair molecules with a two-state "electronic antigen" device comprising a hydroquinone monolayer assembled on gold, and choosing for the pair molecule an antibody that discriminates between the two electrically selected redox states of the monolayer. Application of an oxidative +0.6 V pulse to the antigen switches it to its benzoquinone state where antibodies bind the layer. A subsequent -0.6 V pulse reduces the monolayer back to the unbinding hydroquinone state, releases the specifically bound antibody molecules, and prevents further binding.

Original language	English
Pages (from-to)	3398-3403
Number of pages	6
Journal	Nano Letters
Volume	8
Issue number	10
DOIs	https://doi.org/10.1021/nl8020895
State	Published - Oct 2008
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl8020895

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AU - Artzy-Schnirman, Arbel

AU - Brod, Elad

AU - Epel, Malki

AU - Dines, Monica

AU - Hammer, Tal

AU - Benhar, Itai

AU - Reiter, Yoram

AU - Sivan, Uri

PY - 2008/10

Y1 - 2008/10

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AB - Inspired by biology where pathways are triggered and suppressed by specific binding of two molecules, we realize a functional interface between electronics and biology by replacing one of the pair molecules with a two-state "electronic antigen" device comprising a hydroquinone monolayer assembled on gold, and choosing for the pair molecule an antibody that discriminates between the two electrically selected redox states of the monolayer. Application of an oxidative +0.6 V pulse to the antigen switches it to its benzoquinone state where antibodies bind the layer. A subsequent -0.6 V pulse reduces the monolayer back to the unbinding hydroquinone state, releases the specifically bound antibody molecules, and prevents further binding.

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JO - Nano Letters

JF - Nano Letters

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ER -

A two-state electronic antigen and an antibody selected to discriminate between these states

Abstract

ASJC Scopus subject areas

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