A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a control group

Aviv Segev; Hila Zahava Gvirts; Kevin Strouse; Naama Mayseless; Hagar Gelbard; Yael Doreen Lewis; Yael Barnea; Kfir Feffer; Simone G. Shamay-Tsoory; Yuval Bloch

doi:10.1016/j.psychres.2016.05.009

A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a control group

Aviv Segev, Hila Zahava Gvirts, Kevin Strouse, Naama Mayseless, Hagar Gelbard, Yael Doreen Lewis, Yael Barnea, Kfir Feffer, Simone G. Shamay-Tsoory, Yuval Bloch

Department of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.

Original language	English
Pages (from-to)	232-235
Number of pages	4
Journal	Psychiatry Research
Volume	241
DOIs	https://doi.org/10.1016/j.psychres.2016.05.009
State	Published - 30 Jul 2016

Bibliographical note

Funding Information:
This study was supported by the Israeli Scientific Foundation (ISF), grant number 1194/13; the ISF had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Funding Information:
The authors wish to express their gratitude to Prof. Rachel Tomer for her guidance and assistance. In addition, the authors thank the Israeli Scientific Foundation (ISF) grant number 1194/13 for its support.

Publisher Copyright:
© 2016 Elsevier Ireland Ltd.

Keywords

ADHD
Attention
Cognitive enhancer

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2016.05.009

Cite this

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title = "A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a control group",

abstract = "Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.",

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AU - Barnea, Yael

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AU - Shamay-Tsoory, Simone G.

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A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a control group

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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