Abstract
Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.
Original language | English |
---|---|
Pages (from-to) | 232-235 |
Number of pages | 4 |
Journal | Psychiatry Research |
Volume | 241 |
DOIs | |
State | Published - 30 Jul 2016 |
Bibliographical note
Funding Information:This study was supported by the Israeli Scientific Foundation (ISF), grant number 1194/13; the ISF had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
Funding Information:
The authors wish to express their gratitude to Prof. Rachel Tomer for her guidance and assistance. In addition, the authors thank the Israeli Scientific Foundation (ISF) grant number 1194/13 for its support.
Publisher Copyright:
© 2016 Elsevier Ireland Ltd.
Keywords
- ADHD
- Attention
- Cognitive enhancer
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry