Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.
Bibliographical noteFunding Information:
This study was supported by the Israeli Scientific Foundation (ISF), grant number 1194/13; the ISF had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
The authors wish to express their gratitude to Prof. Rachel Tomer for her guidance and assistance. In addition, the authors thank the Israeli Scientific Foundation (ISF) grant number 1194/13 for its support.
© 2016 Elsevier Ireland Ltd.
- Cognitive enhancer
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry