A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a control group

Aviv Segev; Hila Zahava Gvirts; Kevin Strouse; Naama Mayseless; Hagar Gelbard; Yael Doreen Lewis; Yael Barnea; Kfir Feffer; Simone G. Shamay-Tsoory; Yuval Bloch

doi:10.1016/j.psychres.2016.05.009

A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a control group

Aviv Segev, Hila Zahava Gvirts, Kevin Strouse, Naama Mayseless, Hagar Gelbard, Yael Doreen Lewis, Yael Barnea, Kfir Feffer, Simone G. Shamay-Tsoory, Yuval Bloch

Department of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.

Original language	English
Pages (from-to)	232-235
Number of pages	4
Journal	Psychiatry Research
Volume	241
DOIs	https://doi.org/10.1016/j.psychres.2016.05.009
State	Published - 30 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ireland Ltd.

Keywords

ADHD
Attention
Cognitive enhancer

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2016.05.009

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abstract = "Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.",

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AU - Strouse, Kevin

AU - Mayseless, Naama

AU - Gelbard, Hagar

AU - Lewis, Yael Doreen

AU - Barnea, Yael

AU - Feffer, Kfir

AU - Shamay-Tsoory, Simone G.

AU - Bloch, Yuval

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A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a control group

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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