A population-based family study (II): Segregation analysis

L. P. Zhao, F. Quiaoit, L. Hsu, O. Davidov, S. Holte

Research output: Contribution to journalArticlepeer-review


We used segregation analysis to investigate the genetic etiology of the disease in Problem 2A. Under the assumption of a dominant major gene, our analysis suggests a major gene with relative risk of 58 and an allele frequency of 0.013. Under an additive gene assumption, it appears that there may be two genes with relative risks of 39 and 17 and allele frequencies of 0.015 and 0.075, respectively.

Original languageEnglish
Pages (from-to)945-949
Number of pages5
JournalGenetic Epidemiology
Issue number6
StatePublished - 1997
Externally publishedYes


  • Aggregation
  • Case-control family study
  • Segregation

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology


Dive into the research topics of 'A population-based family study (II): Segregation analysis'. Together they form a unique fingerprint.

Cite this