A population-based family study (II): Segregation analysis

L. P. Zhao; F. Quiaoit; L. Hsu; O. Davidov; S. Holte

doi:10.1002/(SICI)1098-2272(1997)14:6<945::AID-GEPI64>3.0.CO;2-L

A population-based family study (II): Segregation analysis

L. P. Zhao, F. Quiaoit, L. Hsu, O. Davidov, S. Holte

Research output: Contribution to journal › Article › peer-review

Abstract

We used segregation analysis to investigate the genetic etiology of the disease in Problem 2A. Under the assumption of a dominant major gene, our analysis suggests a major gene with relative risk of 58 and an allele frequency of 0.013. Under an additive gene assumption, it appears that there may be two genes with relative risks of 39 and 17 and allele frequencies of 0.015 and 0.075, respectively.

Original language	English
Pages (from-to)	945-949
Number of pages	5
Journal	Genetic Epidemiology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1098-2272(1997)14:6<945::AID-GEPI64>3.0.CO;2-L
State	Published - 1997
Externally published	Yes

Keywords

Aggregation
Case-control family study
Segregation

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/(SICI)1098-2272(1997)14:6<945::AID-GEPI64>3.0.CO;2-L

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abstract = "We used segregation analysis to investigate the genetic etiology of the disease in Problem 2A. Under the assumption of a dominant major gene, our analysis suggests a major gene with relative risk of 58 and an allele frequency of 0.013. Under an additive gene assumption, it appears that there may be two genes with relative risks of 39 and 17 and allele frequencies of 0.015 and 0.075, respectively.",

keywords = "Aggregation, Case-control family study, Segregation",

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T2 - Segregation analysis

AU - Zhao, L. P.

AU - Quiaoit, F.

AU - Hsu, L.

AU - Davidov, O.

AU - Holte, S.

PY - 1997

Y1 - 1997

N2 - We used segregation analysis to investigate the genetic etiology of the disease in Problem 2A. Under the assumption of a dominant major gene, our analysis suggests a major gene with relative risk of 58 and an allele frequency of 0.013. Under an additive gene assumption, it appears that there may be two genes with relative risks of 39 and 17 and allele frequencies of 0.015 and 0.075, respectively.

AB - We used segregation analysis to investigate the genetic etiology of the disease in Problem 2A. Under the assumption of a dominant major gene, our analysis suggests a major gene with relative risk of 58 and an allele frequency of 0.013. Under an additive gene assumption, it appears that there may be two genes with relative risks of 39 and 17 and allele frequencies of 0.015 and 0.075, respectively.

KW - Aggregation

KW - Case-control family study

KW - Segregation

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U2 - 10.1002/(SICI)1098-2272(1997)14:6<945::AID-GEPI64>3.0.CO;2-L

DO - 10.1002/(SICI)1098-2272(1997)14:6<945::AID-GEPI64>3.0.CO;2-L

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JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - 6

ER -

A population-based family study (II): Segregation analysis

Abstract

Keywords

ASJC Scopus subject areas

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