A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

Sarit Larisch, Youngsuk Yi, Rona Lotan, Hedviga Kerner, Sarah Eimerl, W. Tony Parks, Yossi Gottfried, Stephanie Birkey Reffey, Mark P. De Caestecker, David Danielpour, Naomi Book-Melamed, Rina Timberg, Colin S. Duckett, Robert J. Lechleider, Hermann Steller, Joseph Orly, Seong Jin Kim, Anita B. Roberts

Research output: Contribution to journalArticlepeer-review


Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-β signalling pathway). ARTS is expressed in many ceils and acts to enhance cell death induced by TGF-β or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.

Original languageEnglish
Pages (from-to)915-921
Number of pages7
JournalNature Cell Biology
Issue number12
StatePublished - 2000
Externally publishedYes

Bibliographical note

Funding Information:
Ben-Neriah, A. Yaron, S. Gutkind and M. Zohar for discussions and advice; G. Yaniv and O. Binah for providing the neonatal ventricular myocytes; and N. Frumkin and A. H. Hsing for technical assistance. We thank D. B. Hales and K. H. Hales for providing the antiserum to recombinant murine StAR; the AU5–tag expression vector was provided by S. Gutkind; TGF-b receptor constructs were provided by J. Wrana and L. Attisano; and the p3TP–Lux construct was provided by J. Massagué. This work was supported by the Erna D. Leir Foundation for Research of Degenerative Brain Diseases, the National Alliance for Research of Schizophrenia and Depression, the National Parkinson Foundation Inc., the Israel Science Foundation funded by the Israel Academy of Sciences and Humanities (J.O.), and the NIH. H.S. is an investigator of the Howard Hughes Medical Institute. Correspondence and requests for materials should be addressed to A.B.R.

ASJC Scopus subject areas

  • Cell Biology


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