A novel method of multiple alignment of biopolymer sequences

L. I. Brodsky, A. L. Drachev, A. M. Leontovich, S. I. Feranchuk

Research output: Contribution to journalArticlepeer-review


A novel algorithm for multiple alignment of biological sequences is suggested. At the first step the DotHelix procedure is employed for construction of motifs, i.e. continuous fragments of local similarity of various "thickness" and strength, and then these motifs are concatenated into chains consistent with the order of letters in the sequences. The algorithm is implemented in the MA-Tools program of the GeneBee package. An example illustrating the effectivity of the algorithm is presented.

Original languageEnglish
Pages (from-to)65-79
Number of pages15
Issue number1-3
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Applied Mathematics
  • General Biochemistry, Genetics and Molecular Biology
  • Statistics and Probability
  • Modeling and Simulation


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