A novel method of multiple alignment of biopolymer sequences

L. I. Brodsky; A. L. Drachev; A. M. Leontovich; S. I. Feranchuk

doi:10.1016/0303-2647(93)90063-I

A novel method of multiple alignment of biopolymer sequences

L. I. Brodsky, A. L. Drachev, A. M. Leontovich, S. I. Feranchuk

Research output: Contribution to journal › Article › peer-review

Abstract

A novel algorithm for multiple alignment of biological sequences is suggested. At the first step the DotHelix procedure is employed for construction of motifs, i.e. continuous fragments of local similarity of various "thickness" and strength, and then these motifs are concatenated into chains consistent with the order of letters in the sequences. The algorithm is implemented in the MA-Tools program of the GeneBee package. An example illustrating the effectivity of the algorithm is presented.

Original language	English
Pages (from-to)	65-79
Number of pages	15
Journal	BioSystems
Volume	30
Issue number	1-3
DOIs	https://doi.org/10.1016/0303-2647(93)90063-I
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
Applied Mathematics

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10.1016/0303-2647(93)90063-I

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AU - Drachev, A. L.

AU - Leontovich, A. M.

AU - Feranchuk, S. I.

PY - 1993

Y1 - 1993

N2 - A novel algorithm for multiple alignment of biological sequences is suggested. At the first step the DotHelix procedure is employed for construction of motifs, i.e. continuous fragments of local similarity of various "thickness" and strength, and then these motifs are concatenated into chains consistent with the order of letters in the sequences. The algorithm is implemented in the MA-Tools program of the GeneBee package. An example illustrating the effectivity of the algorithm is presented.

AB - A novel algorithm for multiple alignment of biological sequences is suggested. At the first step the DotHelix procedure is employed for construction of motifs, i.e. continuous fragments of local similarity of various "thickness" and strength, and then these motifs are concatenated into chains consistent with the order of letters in the sequences. The algorithm is implemented in the MA-Tools program of the GeneBee package. An example illustrating the effectivity of the algorithm is presented.

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A novel method of multiple alignment of biopolymer sequences

Abstract

ASJC Scopus subject areas

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