A novel geometry-based approach to infer protein interface similarity

Inbal Budowski-Tal, Rachel Kolodny, Yael Mandel-Gutfreund

Research output: Contribution to journalArticlepeer-review

Abstract

The protein interface is key to understand protein function, providing a vital insight on how proteins interact with each other and with other molecules. Over the years, many computational methods to compare protein structures were developed, yet evaluating interface similarity remains a very difficult task. Here, we present PatchBag - a geometry based method for efficient comparison of protein surfaces and interfaces. PatchBag is a Bag-Of-Words approach, which represents complex objects as vectors, enabling to search interface similarity in a highly efficient manner. Using a novel framework for evaluating interface similarity, we show that PatchBag performance is comparable to state-of-the-art alignment-based structural comparison methods. The great advantage of PatchBag is that it does not rely on sequence or fold information, thus enabling to detect similarities between interfaces in unrelated proteins. We propose that PatchBag can contribute to reveal novel evolutionary and functional relationships between protein interfaces.

Original languageEnglish
Article number8192
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - 1 Dec 2018

Bibliographical note

Funding Information:
This work was supported by the Israel Science Foundation Grants No. 1182/16 to Y.M.G. and 450/16 to R.K. I.B.T. was funded in part by the Eshkol fellowship for Doctoral Studies granted by the Israeli Ministry of Science, Technology and Space. We would like to thank Liad Cohen for extensive help in testing PatchBag and for helpful discussions.

Publisher Copyright:
© 2018 The Author(s).

ASJC Scopus subject areas

  • General

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