A molecular switch for translational control in taste memory consolidation

K. Belelovsky, A. Elkobi, H. Kaphzan, A. C. Nairn, K. Rosenblum

Research output: Contribution to journalArticlepeer-review


In a variety of species memory consolidation following different learning paradigms has been shown to be dependent on protein synthesis. However, it is not known whether modulation of protein synthesis is a critical component of the consolidation process, nor is the identity of any protein(s) subject to translational regulation, known. We report here that phosphorylation of eukaryotic elongation factor-2 (eEF2), an indicator for translational elongation attenuation, is correlated with input that produces taste memory consolidation in the relevant cortex of rat. The temporal pattern of eEF2 phosphorylation is similar to extra-cellular regulated kinase 2 (ERK2) activation and S6K1 phosphorylation, which are known to stimulate translation initiation. In addition, increased eEF2 phosphorylation and increased αCaMKII expression is detected in a synaptoneurosomal fraction made from taste cortex following memory consolidation. These results suggest that increased initiation rate together with decreased elongation rate, during memory consolidation, shift the rate-limiting step of protein synthesis, to produce a local switch-like effect in the expression of neuronal proteins.

Original languageEnglish
Pages (from-to)2560-2568
Number of pages9
JournalEuropean Journal of Neuroscience
Issue number10
StatePublished - Nov 2005


  • ERK1/2
  • Long-term memory
  • Rat
  • Translation regulation
  • eEF2

ASJC Scopus subject areas

  • General Neuroscience


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