A molecular mechanism underlying gustatory memory trace for an association in the insular cortex

Chinnakkaruppan Adaikkan, Kobi Rosenblum

Research output: Contribution to journalArticlepeer-review

Abstract

Events separated in time are associatively learned in trace conditioning, recruiting more neuronal circuits and molecular mechanisms than in delay conditioning. However, it remains unknown whether a given sensory memory trace is being maintained as a unitary item to associate. Here, we used conditioned taste aversion learning in the rat model, wherein animals associate a novel taste with visceral nausea, and demonstrate that there are two parallel memory traces of a novel taste: a short-duration robust trace, lasting approximately 3 hr, and a parallel long-duration weak one, lasting up to 8 hr, and dependent on the strong trace for its formation. Moreover, only the early robust trace is maintained by a NMDAR-dependent CaMKII-AMPAR pathway in the insular cortex. These findings suggest that a memory trace undergoes rapid modifications, and that the mechanisms underlying trace associative learning differ when items in the memory are experienced at different time points.

Original languageEnglish
Article numbere07582
JournaleLife
Volume4
Issue numberOCTOBER2015
DOIs
StatePublished - 9 Oct 2015

Bibliographical note

Publisher Copyright:
© Adaikkan and Rosenblum.

ASJC Scopus subject areas

  • Neuroscience (all)
  • Immunology and Microbiology (all)
  • Biochemistry, Genetics and Molecular Biology (all)

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