A model of the hippocampus combining selforganization and associative memory function.

Michael E. Hasselmo; Eric Schnell; Joshua Berke; Edi Barkai

A model of the hippocampus combining selforganization and associative memory function.

Michael E. Hasselmo, Eric Schnell, Joshua Berke, Edi Barkai

Research output: Contribution to conference › Paper › peer-review

Abstract

A model of the hippocampus is presented which forms rapid self-organized representations of input arriving via the perforant path, performs recall of previous associations in region CA3, and performs comparison of this recall with afferent input in region CA1. This comparison drives feedback regulation of cholinergic modulation to set appropriate dynamics for learning of new representations in region CA3 and CA1. The network responds to novel patterns with increased cholinergic modulation, allowing storage of new self-organized representations, but responds to familiar patterns with a decrease in acetylcholine, allowing recall based on previous representations. This requires selectivity of the cholinergic suppression of synaptic transmission in stratum radiatum of regions CA3 and CA1, which has been demonstrated experimentally.

Original language	English
Pages	77-84
Number of pages	8
State	Published - 1994
Externally published	Yes
Event	7th International Conference on Neural Information Processing Systems, NIPS 1994 - Denver, United States Duration: 1 Jan 1994 → 1 Jan 1994

Conference

Conference	7th International Conference on Neural Information Processing Systems, NIPS 1994
Country/Territory	United States
City	Denver
Period	1/01/94 → 1/01/94

Bibliographical note

Publisher Copyright:
© NIPS 1994.All rights reserved.

ASJC Scopus subject areas

Information Systems
Signal Processing
Computer Networks and Communications

Cite this

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title = "A model of the hippocampus combining selforganization and associative memory function.",

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pages = "77--84",

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AU - Schnell, Eric

AU - Berke, Joshua

AU - Barkai, Edi

PY - 1994

Y1 - 1994

N2 - A model of the hippocampus is presented which forms rapid self-organized representations of input arriving via the perforant path, performs recall of previous associations in region CA3, and performs comparison of this recall with afferent input in region CA1. This comparison drives feedback regulation of cholinergic modulation to set appropriate dynamics for learning of new representations in region CA3 and CA1. The network responds to novel patterns with increased cholinergic modulation, allowing storage of new self-organized representations, but responds to familiar patterns with a decrease in acetylcholine, allowing recall based on previous representations. This requires selectivity of the cholinergic suppression of synaptic transmission in stratum radiatum of regions CA3 and CA1, which has been demonstrated experimentally.

AB - A model of the hippocampus is presented which forms rapid self-organized representations of input arriving via the perforant path, performs recall of previous associations in region CA3, and performs comparison of this recall with afferent input in region CA1. This comparison drives feedback regulation of cholinergic modulation to set appropriate dynamics for learning of new representations in region CA3 and CA1. The network responds to novel patterns with increased cholinergic modulation, allowing storage of new self-organized representations, but responds to familiar patterns with a decrease in acetylcholine, allowing recall based on previous representations. This requires selectivity of the cholinergic suppression of synaptic transmission in stratum radiatum of regions CA3 and CA1, which has been demonstrated experimentally.

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M3 - Paper

AN - SCOPUS:85153963383

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T2 - 7th International Conference on Neural Information Processing Systems, NIPS 1994

Y2 - 1 January 1994 through 1 January 1994

ER -

A model of the hippocampus combining selforganization and associative memory function.

Abstract

Conference

Bibliographical note

ASJC Scopus subject areas

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Cite this