A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk

Alisa Manning, Heather M. Highland, Jessica Gasser, Xueling Sim, Taru Tukiainen, Pierre Fontanillas, Niels Grarup, Manuel A. Rivas, Anubha Mahajan, Adam E. Locke, Pablo Cingolani, Tune H. Pers, Ana Viñuela, Andrew A. Brown, Ying Wu, Jason Flannick, Christian Fuchsberger, Eric R. Gamazon, Kyle J. Gaulton, Hae Kyung ImTanya M. Teslovich, Thomas W. Blackwell, Jette Bork-Jensen, Noël P. Burtt, Yuhui Chen, Todd Green, Christopher Hartl, Hyun Min Kang, Ashish Kumar, Claes Ladenvall, Clement Ma, Loukas Moutsianas, Richard D. Pearson, John R.B. Perry, N. William Rayner, Neil R. Robertson, Laura J. Scott, Martijn van de Bunt, Johan G. Eriksson, Antti Jula, Seppo Koskinen, Terho Lehtimäki, Aarno Palotie, Olli T. Raitakari, Suzanne B.R. Jacobs, Jennifer Wessel, Audrey Y. Chu, Robert A. Scott, Mark O. Goodarzi, Christine Blancher, Gemma Buck, David Buck, Peter S. Chines, Stacey Gabriel, Anette P. Gjesing, Christopher J. Groves, Mette Hollensted, Jeroen R. Huyghe, Anne U. Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S. Small, Heather M. Stringham, Joseph Trakalo, Eric Banks, Jason Carey, Mauricio O. Carneiro, Mark Depristo, Yossi Farjoun, Timothy Fennell, Jacqueline I. Goldstein, George Grant, Martin Hrabé de Angelis, Jared Maguire, Benjamin M. Neale, Ryan Poplin, Shaun Purcell, Thomas Schwarzmayr, Khalid Shakir, Joshua D. Smith, Tim M. Strom, Thomas Wieland, Jaana Lindstrom, Ivan Brandslund, Cramer Christensen, Gabriela L. Surdulescu, Timo A. Lakka, Alex S.F. Doney, Peter Nilsson, Nicholas J. Wareham, Claudia Langenberg, Tibor V. Varga, Paul W. Franks, Olov Rolandsson, Anders H. Rosengren, Vidya S. Farook, Farook Thameem, Sobha Puppala, Satish Kumar, Donna M. Lehman, Christopher P. Jenkinson, Joanne E. Curran, Daniel Esten Hale, Sharon P. Fowler, Rector Arya, Ralph A. Defronzo, Hanna E. Abboud, Ann Christine Syvänen, Pamela J. Hicks, Nicholette D. Palmer, Maggie C.Y. Ng, Donald W. Bowden, Barry I. Freedman, Tõnu Esko, Reedik Mägi, Lili Milani, Evelin Mihailov, Andres Metspalu, Narisu Narisu, Leena Kinnunen, Lori L. Bonnycastle, Amy Swift, Dorota Pasko, Andrew R. Wood, João Fadista, Toni I. Pollin, Nir Barzilai, Gil Atzmon, Benjamin Glaser, Barbara Thorand, Konstantin Strauch, Annette Peters, Michael Roden, Martina Müller-Nurasyid, Liming Liang, Jennifer Kriebel, Thomas Illig, Harald Grallert, Christian Gieger, Christa Meisinger, Lars Lannfelt, Solomon K. Musani, Michael Griswold, Herman A. Taylor, Gregory Wilson, Adolfo Correa, Heikki Oksa, William R. Scott, Uzma Afzal, Sian Tsung Tan, Marie Loh, John C. Chambers, Jobanpreet Sehmi, Jaspal Singh Kooner, Benjamin Lehne, Yoon Shin Cho, Jong Young Lee, Bok Ghee Han, Annemari Käräjämäki, Qibin Qi, Lu Qi, Jinyan Huang, Frank B. Hu, Ol L. E Mel Ander, Marju Orho-Melander, Jennifer E. Below, David Aguilar, Tien Yin Wong, Jianjun Li U, Chiea Chuen Khor, Kee Seng Chia, Wei Yen Lim, Ching Yu Cheng, Edmund Chan, E. Shyong Tai, Tin Aung, Allan Linneberg, Bo Isomaa, Thomas Meitinger, Tiinamaija Tuomi, Liisa Hakaste, Jasmi Na Kravi C, Marit E. Jørgensen, Torsten Lauritzen, Panos Deloukas, Kathleen E. Stirrups, Kat Har Kat, Andrew J. Farmer, Timothy M. Frayling, Stephen P. O’rahilly, Mark Walker, Jonathan C. Levy, Dylan Hodgkiss, Andrew T. Hattersley, Teemu Kuulasmaa, Alena Stan?cáková, Inês Barroso, Dwaipayan Bharadwaj, Juliana Chan, Giriraj R. Chandak, Mark J. Daly, Peter J. Donnelly, Shah B. Ebrahim, Paul Elliott, Tasha Fingerlin, Philippe Froguel, Cheng Hu, Weiping Jia, Ronald C.W. Ma, Gilean McVean, Taesung Park, Dorairaj Prabhakaran, Manjinder Sandhu, James Scott, Rob Sladek, Nikhil Tandon, Yik Ying Teo, Eleftheria Zeggini, Richard M. Watanabe, Heikki A. Koistinen, Y. Antero Kesaniemi, Matti Uusitupa, Timothy D. Spector, Veikko Salomaa, Rainer Rauramaa, Colin N.A. Palmer, Inga Prokopenko, Andrew D. Morris, Richard N. Bergman, Francis S. Collins, Lars Lind, Erik Ingelsson, Jaakko Tuomilehto, Fredrik Karpe, Leif Groop, Torben Jørgensen, Torben Hansen, Oluf Pedersen, Johanna Kuusisto, Gonçalo Abecasis, Graeme I. Bell, John Blangero, Nancy J. Cox, Ravindranath Duggirala, Mark Seielstad, James G. Wilson, Josee Dupuis, Samuli Ripatti, Craig L. Hanis, Jose C. Florez, Karen L. Mohlke, James B. Meigs, Markku Laakso, Andrew P. Morris, Michael Boehnke, David Altshuler, Mark I. McCarthy, Anna L. Gloyn, Cecilia M. Lindgren

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Biochemistry, Genetics and Molecular Biology