A Kelch domain-containing f-box coding gene negatively regulates flavonoid accumulation in muskmelon

Ari Feder, Joseph Burger, Shan Gao, Efraim Lewinsohn, Nurit Katzir, Arthur A. Schaffer, Ayala Meir, Rachel Davidovich-Rikanat, Vitaly Portnoy, Amit Gal-On, Zhangjun Fei, Yechezkel Kashi, Yaakov Tadmor

Research output: Contribution to journalArticlepeer-review


The flavonoids are phenylpropanoid-derived metabolites that are ubiquitous in plants, playing many roles in growth and development. Recently, we observed that fruit rinds of yellow casaba muskmelons (Cucumis melo ‘Inodorous Group’) accumulate naringenin chalcone, a yellow flavonoid pigment. With RNA-sequencing analysis of bulked segregants representing the tails of a population segregating for naringenin chalcone accumulation followed by fine mapping and genetic transformation, we identified a Kelch domain-containing F-box protein coding (CmKFB) gene that, when expressed, negatively regulates naringenin chalcone accumulation. Additional metabolite analysis indicated that downstream flavonoids are accumulated together with naringenin chalcone, whereas CmKFB expression diverts the biochemical flux toward coumarins and general phenylpropanoids. These results show that CmKFB functions as a posttranscriptional regulator that diverts flavonoid metabolic flux.

Original languageEnglish
Pages (from-to)1714-1726
Number of pages13
JournalPlant Physiology
Issue number3
StatePublished - Nov 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 American Society of Plant Biologists. All rights Reserved.

ASJC Scopus subject areas

  • Physiology
  • Genetics
  • Plant Science


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