A critique of functional localisers

K. J. Friston; P. Rotshtein; J. J. Geng; P. Sterzer; R. N. Henson

doi:10.1016/j.neuroimage.2005.08.012

A critique of functional localisers

K. J. Friston, P. Rotshtein, J. J. Geng, P. Sterzer, R. N. Henson

Research output: Contribution to journal › Comment/Debate

Abstract

In this critique, we review the usefulness of functional localising scans in functional MRI studies. We consider their conceptual motivations and the implications for experimental design and inference. Functional localisers can often be viewed as acquiring data from cells that have been removed from an implicit factorial design. This perspective reveals their potentially restrictive nature. We deconstruct two examples from the recent literature to highlight the key issues. We conclude that localiser scans can be unnecessary and, in some instances, lead to a biased and inappropriately constrained characterisation of functional anatomy.

Original language	English
Pages (from-to)	1077-1087
Number of pages	11
Journal	NeuroImage
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.neuroimage.2005.08.012
State	Published - 1 May 2006
Externally published	Yes

Bibliographical note

Funding Information:
The Wellcome Trust supported this work. We thank very much Marcia Bennett for preparing the manuscript. We would like to thank Cathy Price, John Haynes and Jon Driver for invaluable contributions. We would also like to thank Zoë Kourtzi and Scott Slotnick, for ensuring that their original findings were properly represented in this discussion.

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2005.08.012

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abstract = "In this critique, we review the usefulness of functional localising scans in functional MRI studies. We consider their conceptual motivations and the implications for experimental design and inference. Functional localisers can often be viewed as acquiring data from cells that have been removed from an implicit factorial design. This perspective reveals their potentially restrictive nature. We deconstruct two examples from the recent literature to highlight the key issues. We conclude that localiser scans can be unnecessary and, in some instances, lead to a biased and inappropriately constrained characterisation of functional anatomy.",

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AU - Friston, K. J.

AU - Rotshtein, P.

AU - Geng, J. J.

AU - Sterzer, P.

AU - Henson, R. N.

N1 - Funding Information: The Wellcome Trust supported this work. We thank very much Marcia Bennett for preparing the manuscript. We would like to thank Cathy Price, John Haynes and Jon Driver for invaluable contributions. We would also like to thank Zoë Kourtzi and Scott Slotnick, for ensuring that their original findings were properly represented in this discussion.

PY - 2006/5/1

Y1 - 2006/5/1

N2 - In this critique, we review the usefulness of functional localising scans in functional MRI studies. We consider their conceptual motivations and the implications for experimental design and inference. Functional localisers can often be viewed as acquiring data from cells that have been removed from an implicit factorial design. This perspective reveals their potentially restrictive nature. We deconstruct two examples from the recent literature to highlight the key issues. We conclude that localiser scans can be unnecessary and, in some instances, lead to a biased and inappropriately constrained characterisation of functional anatomy.

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A critique of functional localisers

Abstract

Bibliographical note

ASJC Scopus subject areas

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