A comparative study of reproductive and metabolic responses to administration of exogenous melatonin and aldosterone in xeric and mesic spiny mice populations

Elena Bukovetzky, Abraham Haim

Research output: Contribution to journalArticlepeer-review

Abstract

A comparative study of reproduction revealed differences between desert-adapted Acomys russatus and Mediterranean Acomys cahirinus populations with respect to the environmental cues used for reproductive activity. Long day (LD) conditions were noted as initial reproductive cue for both populations. This research is a follow-up affects comparative endocrine and metabolic study in regards to reproduction where LD-acclimated mice were treated with, exogenous aldosterone (ALDO) and melatonin (MLT). Only the reproductive system of A. russatus females was significantly affected by both hormones. In A. cahirinus females, MLT decreased leptin levels, while in A. russatus, a treatment with both hormones increased leptin levels. In A. russatus males, MLT affects both reproductive and metabolic functions. However, in A. cahirinus males, ALDO and MLT treatments caused an increase in leptin levels, and a decrease in free fatty acid (FFA) levels, respectively. Correlations between leptin and FFA in general were affected by both MLT and ALDO treatments in A. russatus males and A. cahirinus females. Our results support the general idea, that although the reproductive system of A. russatus responded to an osmotic stress, in our case expressed by ALDO treatment, which can be considered as an ultimate signal, where, photoperiod changes are an initial signal.

Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume173
DOIs
StatePublished - Jul 2014
Externally publishedYes

Bibliographical note

Funding Information:
We thank the ISF ( Israel Academy of Science and Humanities ) for financial support through a grant to Abraham Haim and Fuad Fares. We also would like to thank Dr. Lilach Ashkenazi for her help and constructive comments. We thank Ms. Nina Dinov and the staff of the Department of Biology at the Oranim Campus for their assistance in maintaining the animals. The authors also thank the two anonymous reviewers for their constructive comments on this paper.

Keywords

  • Acomys
  • Aldosterone
  • Melatonin
  • Metabolic status
  • Photoperiod
  • Reproductive status
  • White adipose tissue
  • Xeric adaptation

ASJC Scopus subject areas

  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Biochemistry
  • Physiology

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