Abstract
Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems.
| Original language | English |
|---|---|
| Pages (from-to) | 16-22 |
| Number of pages | 7 |
| Journal | Prostaglandins and Other Lipid Mediators |
| Volume | 106 |
| DOIs | |
| State | Published - Oct 2013 |
Bibliographical note
Publisher Copyright:© 2013
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Arachidonic acid
- Docosahexaenoic acid
- Lipoxygenase
- Neoplastic growth
- Tumor biology
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Pharmacology
- Cell Biology
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