15-Lipoxygenases in cancer: A double-edged sword?

Adi J. Klil-Drori; Amiram Ariel

doi:10.1016/j.prostaglandins.2013.07.006

15-Lipoxygenases in cancer: A double-edged sword?

Adi J. Klil-Drori, Amiram Ariel

Research output: Contribution to journal › Review article › peer-review

Abstract

Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems.

Original language	English
Pages (from-to)	16-22
Number of pages	7
Journal	Prostaglandins and Other Lipid Mediators
Volume	106
DOIs	https://doi.org/10.1016/j.prostaglandins.2013.07.006
State	Published - Oct 2013

Bibliographical note

Publisher Copyright:
© 2013

Keywords

Arachidonic acid
Docosahexaenoic acid
Lipoxygenase
Neoplastic growth
Tumor biology

ASJC Scopus subject areas

Biochemistry
Physiology
Pharmacology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.prostaglandins.2013.07.006

Cite this

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title = "15-Lipoxygenases in cancer: A double-edged sword?",

abstract = "Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems.",

keywords = "Arachidonic acid, Docosahexaenoic acid, Lipoxygenase, Neoplastic growth, Tumor biology",

author = "Klil-Drori, {Adi J.} and Amiram Ariel",

note = "Publisher Copyright: {\textcopyright} 2013",

year = "2013",

month = oct,

doi = "10.1016/j.prostaglandins.2013.07.006",

language = "English",

volume = "106",

pages = "16--22",

journal = "Prostaglandins and Other Lipid Mediators",

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TY - JOUR

T1 - 15-Lipoxygenases in cancer

T2 - A double-edged sword?

AU - Klil-Drori, Adi J.

AU - Ariel, Amiram

PY - 2013/10

Y1 - 2013/10

N2 - Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems.

AB - Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems.

KW - Arachidonic acid

KW - Docosahexaenoic acid

KW - Lipoxygenase

KW - Neoplastic growth

KW - Tumor biology

UR - http://www.scopus.com/inward/record.url?scp=84901944190&partnerID=8YFLogxK

U2 - 10.1016/j.prostaglandins.2013.07.006

DO - 10.1016/j.prostaglandins.2013.07.006

M3 - Review article

C2 - 23933488

AN - SCOPUS:84901944190

SN - 1098-8823

VL - 106

SP - 16

EP - 22

JO - Prostaglandins and Other Lipid Mediators

JF - Prostaglandins and Other Lipid Mediators

ER -

15-Lipoxygenases in cancer: A double-edged sword?

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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