15-Lipoxygenases in cancer: A double-edged sword?

Adi J. Klil-Drori, Amiram Ariel

Research output: Contribution to journalReview articlepeer-review

Abstract

Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalProstaglandins and Other Lipid Mediators
Volume106
DOIs
StatePublished - Oct 2013

Bibliographical note

Publisher Copyright:
© 2013

Keywords

  • Arachidonic acid
  • Docosahexaenoic acid
  • Lipoxygenase
  • Neoplastic growth
  • Tumor biology

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cell Biology
  • Pharmacology

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