Abstract
The effects of exogenous recombinant human heat shock protein Hsp70 and hydrogen sulfide donor GYY4137 on the mechanisms of endocytosis of lipopolysaccharide (LPS) by human neuroblastoma cells SH-SY5Ywas studied. Hsp70 and GYY4137 have been shown to significantly reduce LPS-induced production of inflammatory mediators by SH-SY5Y cells, including reactive oxygen species, nitric oxide, TNFα, IL-1β, and IL-6. Both the recombinant protein Hsp70 and the hydrogen sulfide donor GYY4137 exhibited significant protective effects; however, the combined use of these agents did not lead to a cumulative effect. It has been shown that pinocytosis, as well as clathrin-, caveolin-, tubulin- and receptor-dependent endocytosis were involved in protecting the cells by both the hydrogen sulfide donor and Hsp70 from LPS-induced production of reactive oxygen species and NO.
| Original language | Russian |
|---|---|
| Pages (from-to) | 1018-1028 |
| Number of pages | 11 |
| Journal | Molekulyarnaya Biologiya |
| Volume | 54 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1 Nov 2020 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cell Line, Tumor
- Cytokines
- HSP70 Heat-Shock Proteins/metabolism
- Humans
- Hydrogen Sulfide/pharmacology
- Lipopolysaccharides/pharmacology
- Morpholines/pharmacology
- Organothiophosphorus Compounds/pharmacology
- Reactive Oxygen Species/metabolism
- Recombinant Proteins/metabolism
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